概述

  • 产品名称
  • 描述
    兔多克隆抗体to CARD9
  • 经测试应用
    适用于: WB, IHC-P, ICCmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Dog
  • 免疫原

    Synthetic peptide:

    DRENTTGSDNTDTEGS

    conjugated to KLH, corresponding to amino acids 521-536 of Human CARD9 (NP_434700.2).

  • 阳性对照
    • Human adrenal tissue.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -80°C.
  • 存储溶液
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115578 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 62 kDa.Can be blocked with Human CARD9 peptide (ab9650).
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC Use at an assay dependent concentration.

靶标

  • 功能
    Activates NF-kappa-B via BCL10.
  • 组织特异性
    Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
  • 疾病相关
    Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2) [MIM:212050]. Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis.
  • 序列相似性
    Contains 1 CARD domain.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CANDF2 antibody
    • CARD9 antibody
    • CARD9_HUMAN antibody
    • Caspase recruitment domain family member 9 antibody
    • Caspase recruitment domain-containing protein 9 antibody
    • hCARD9 antibody
    see all

图片

  • ab115578, at 10µg/ml, staining CARD9 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

文献

ab115578 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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