• 产品名称Anti-CARD14抗体
    参阅全部 CARD14 一抗
  • 描述
    兔多克隆抗体to CARD14
  • 经测试应用适用于: IHC-Fr, WB, Dot Blot, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Monkey
  • 免疫原

    Synthetic peptide corresponding to the internal portion of Human CARD14.

  • 阳性对照
    • Jurkat whole cell lysate.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域



Our Abpromise guarantee covers the use of ab64366 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use a concentration of 2.5 - 20 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 130 kDa (predicted molecular weight: 113 kDa).
Dot Blot Use at an assay dependent concentration.
ELISA Use a concentration of 0.1 - 1 µg/ml.


  • 功能Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • 组织特异性Expressed in placenta. Also detected in HeLaS3 cell line, but not in the other cancer cell lines tested. Expressed in epidermal keratinocytes.
  • 疾病相关Defects in CARD14 are the cause of susceptibility to psoriasis type 2 (PSORS2) [MIM:602723]. A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
    Defects in CARD14 are the cause of pityriasis rubra pilaris (PRP) [MIM:173200]. A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
  • 序列相似性Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Bcl10 interacting MAGUK protein 2 antibody
    • Bimp 2 antibody
    • Bimp2 antibody
    • CAR14_HUMAN antibody
    • CARD 14 antibody
    • CARD containing MAGUK 2 protein antibody
    • CARD containing MAGUK protein 2 antibody
    • Card maguk protein 2 antibody
    • CARD-containing MAGUK protein 2 antibody
    • CARD14 antibody
    • Carma 2 antibody
    • Carma2 antibody
    • Caspase recruitment domain containing protein 14 antibody
    • Caspase recruitment domain family member 14 antibody
    • Caspase recruitment domain protein 14 antibody
    • Caspase recruitment domain-containing protein 14 antibody
    • PRP antibody
    • PSORS2 antibody
    • PSS1 antibody
    see all

Anti-CARD14 antibody 图像

  • Anti-CARD14 antibody (ab64366) at 1/200 dilution + Jurkat whole cell lysate at 15 µg

    Predicted band size : 113 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)
  • ab64366 at 10µg/ml staining CARD14 in Human placenta by Immunohistichemistry (frozen sections).Localization of the antibody can be seen as the precipitated red signal. A hematoxylin purple nuclear counterstain in placental trophoblasts has been used.

Anti-CARD14 antibody (ab64366)参考文献

ab64366 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. I was not able to obtain the exact sequence of the immunogen but I did receive a range that contains it: amino acids 410-435 of human CARD14, which is PPGVLKQEARTREPCPREKQRLVRMH I hope this information is helpful...

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