RabMAb

Anti-CARD11抗体[EPR3177] (ab109310)

概述

  • 产品名称Anti-CARD11抗体[EPR3177]
    参阅全部 CARD11 一抗
  • 描述
    兔单克隆抗体[EPR3177] to CARD11
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide, corresponding to residues on the C terminus of Human CARD11.

  • 阳性对照
    • K562 and Ramos cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab109310 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 130 kDa (predicted molecular weight: 133 kDa).
ICC/IF 1/50 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
    • 组织特异性Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.
    • 序列相似性Contains 1 CARD domain.
      Contains 1 guanylate kinase-like domain.
      Contains 1 PDZ (DHR) domain.
    • 翻译后修饰Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
    • 细胞定位Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 0610008L17Rik antibody
      • 2410011D02Rik antibody
      • Bcl10 interacting maguk protein 3 antibody
      • BIMP 3 antibody
      • BIMP3 antibody
      • CAR11_HUMAN antibody
      • CARD 11 antibody
      • CARD containing MAGUK protein 3 antibody
      • Card maguk protein 1 antibody
      • CARD-containing MAGUK protein 1 antibody
      • CARD11 antibody
      • CARD11 protein antibody
      • Carma 1 antibody
      • CARMA1 antibody
      • Caspase recruitment domain containing protein 11 antibody
      • Caspase recruitment domain family member 11 antibody
      • Caspase recruitment domain-containing protein 11 antibody
      • MGC133069 antibody
      see all

    Anti-CARD11 antibody [EPR3177] 图像

    • All lanes : Anti-CARD11 antibody [EPR3177] (ab109310) at 1/1000 dilution

      Lane 1 : K562 cell lysates
      Lane 2 : Ramos cell lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 133 kDa
      Observed band size : 130 kDa (why is the actual band size different from the predicted?)

    Anti-CARD11 antibody [EPR3177] (ab109310)参考文献

    ab109310 has not yet been referenced specifically in any publications.

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