概述

  • 产品名称Anti-CARD11抗体
    参阅全部 CARD11 一抗
  • 描述
    兔多克隆抗体to CARD11
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow
  • 免疫原

    Recombinant Human CARD11.

  • 阳性对照
    • Human Liver and Brain cerebellum tissues; A431 and Raji whole cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab113409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 133 kDa.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • 组织特异性Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.
  • 序列相似性Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • 翻译后修饰Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
  • 细胞定位Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 0610008L17Rik antibody
    • 2410011D02Rik antibody
    • Bcl10 interacting maguk protein 3 antibody
    • BIMP 3 antibody
    • BIMP3 antibody
    • CAR11_HUMAN antibody
    • CARD 11 antibody
    • CARD containing MAGUK protein 3 antibody
    • Card maguk protein 1 antibody
    • CARD-containing MAGUK protein 1 antibody
    • CARD11 antibody
    • CARD11 protein antibody
    • Carma 1 antibody
    • CARMA1 antibody
    • Caspase recruitment domain containing protein 11 antibody
    • Caspase recruitment domain family member 11 antibody
    • Caspase recruitment domain-containing protein 11 antibody
    • MGC133069 antibody
    see all

Anti-CARD11 antibody 图像

  • ab113409 at 10 µg/ml staining CARD11 in Human liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab113409 at 10 µg/ml staining CARD11 in Human cerebellum by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • All lanes : Anti-CARD11 antibody (ab113409) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 133 kDa

Anti-CARD11 antibody (ab113409)参考文献

ab113409 has not yet been referenced specifically in any publications.

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