概述

  • 产品名称Anti-Carboxypeptidase H抗体
    参阅全部 Carboxypeptidase H 一抗
  • 描述
    兔多克隆抗体to Carboxypeptidase H
  • 特异性Ab11053 recognises carboxypeptidase H.
  • 经测试应用适用于: ICC, IHC-Fr, IP, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human, Monkey
  • 免疫原

    Synthetic peptide corresponding to Human Carboxypeptidase H (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    LQQEDGISFE

  • 阳性对照
    • Secretory granules of the pancreatic islets, adrenal gland and pituitary gland.
  • 常规说明Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

应用

Our Abpromise guarantee covers the use of ab11053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC
IHC-Fr
IP
WB
  • 应用说明ICC: 1/100 - 1/400.
    IHC-Fr: Use at an assay dependent dilution. Methanol fixation for this purpose is recommended.
    IP: Use at an assay dependent dilution. Pre-treatment with 0.1% w/v SDS and 1% v/v TritonX 100 required.
    WB: 1/500 - 1/1000. Predicted molecular weight: 53.2 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
    • 组织特异性Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
    • 序列相似性Belongs to the peptidase M14 family.
    • 细胞定位Nucleus and Secreted. Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Carboxypeptidase E antibody
      • Carboxypeptidase H antibody
      • Carboxypeptidase H precursor antibody
      • CarboxypeptidaseE antibody
      • CarboxypeptidaseH antibody
      • CBPE_HUMAN antibody
      • Cobalt stimulated chromaffin granule carboxypeptidase antibody
      • CPE antibody
      • Cph 1 antibody
      • CPH antibody
      • Enkephalin convertase antibody
      • Entephalin convertase antibody
      • Insulin granule associated carboxypeptidase antibody
      • Prohormone processing carboxypeptidase antibody
      • Prohormone-processing carboxypeptidase antibody
      see all

    Anti-Carboxypeptidase H antibody (ab11053)参考文献

    This product has been referenced in:
    • Parkinson D Carboxypeptidase H in bovine pituitary gland: soluble forms are not processed at the C-terminus. Mol Cell Endocrinol 86:221-33 (1992). Read more (PubMed: 1511790) »
    • Fiedorek FT & Parkinson D Carboxypeptidase H processing and secretion in rat clonal beta-cell lines. Endocrinology 131:1054-62 (1992). Read more (PubMed: 1505450) »

    See all 2 Publications for this product

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