Anti-Carboxypeptidase B2抗体[13H4] (HRP) (ab14757)

概述

  • 产品名称Anti-Carboxypeptidase B2抗体[13H4] (HRP)
    参阅全部 Carboxypeptidase B2 一抗
  • 描述
    小鼠单克隆抗体[13H4] to Carboxypeptidase B2 (HRP)
  • 偶联物HRP
  • 经测试应用适用于: WB, ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein (purified) (Human).

性能

应用

Our Abpromise guarantee covers the use of ab14757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 50.8 kDa.
ELISA Use at an assay dependent dilution. Can be paired for ELISA with Mouse monoclonal [13D5] to Carboxypeptidase B2 (ab14756).
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [13D5] to Carboxypeptidase B2 (ab14756). Can be used as Detection antibody.

靶标

  • 相关性This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 – 10 µg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • 1110032P04Rik antibody
    • 4930405E17Rik antibody
    • bA139H14.2 antibody
    • Carboxypeptidase B like protein antibody
    • Carboxypeptidase U antibody
    • CarboxypeptidaseB2 antibody
    • CarboxypeptidaseU antibody
    • CP B2 antibody
    • CPB 2 antibody
    • CPB2 antibody
    • CPU antibody
    • PCPB antibody
    • Plasma carboxypeptidase B antibody
    • Plasma carboxypeptidase B2 antibody
    • Procarboxypeptidase B antibody
    • Procarboxypeptidase R antibody
    • Procarboxypeptidase U antibody
    • TAFI antibody
    • Thrombin activable fibrinolysis inhibitor antibody
    • Thrombin activatable fibrinolysis inhibitor antibody
    see all

Anti-Carboxypeptidase B2 antibody [13H4] (HRP) 图像

  • Titration curves of carboxypeptidase B2 in plasma using antibody pair; capture ab14756, 200ng/well and HRPconjugated antibody ab14757. Incubated at room temperature.



  • Predicted band size : 50.8 kDa


    Detection of carboxypeptidease B2 (TAFI) with ab14757 [13H4] in western blotting (non reducing conditions)

Anti-Carboxypeptidase B2 antibody [13H4] (HRP) (ab14757)参考文献

This product has been referenced in:
  • Acosta-Martin AE  et al. Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. PLoS One 6:e28698 (2011). WB ; Human . Read more (PubMed: 22163325) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"