Antitumor agent; blocks DNA replication and transcription. Cisplatin analog.
生物学描述Antitumor agent. Forms platinum-DNA adducts blocking DNA replication and transcription. Displays lower nephrotoxicity than analog, cisplatin (ab141398). Active in vivo.
存放说明Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in water to 25 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Mlcouskova J et al. Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding. J Biol Inorg Chem17:891-8 (2012).
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Thomas JP et al. High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol Pharmacol70:23-9 (2006).
Read more (PubMed: 16569706) »