Carboplatin,Antitumor agent (ab120828)
Key features and details
- Antitumor agent; blocks DNA replication and transcription. Cisplatin analog.
- CAS Number: 41575-94-4
- Purity: > 99%
- Soluble in water to 25 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Carboplatin,Antitumor agent -
描述
Antitumor agent; blocks DNA replication and transcription. Cisplatin analog. -
生物学描述
Antitumor agent. Forms platinum-DNA adducts blocking DNA replication and transcription. Displays lower nephrotoxicity than analog, cisplatin (ab141398). Active in vivo.
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纯度
> 99% -
CAS编号
41575-94-4 -
化学结构
性能
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化学名称
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum (II) -
分子量
371.25 -
分子式
C6H12N2O4Pt -
PubChem识别号
426756 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM and in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2] -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120828 被引用在 3 文献中.
- Gonzalez Rajal A et al. A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma. Elife 10:N/A (2021). PubMed: 33983115
- Hastings JF et al. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. Elife 9:N/A (2020). PubMed: 32513387
- Ke FY et al. Novel monoclonal antibody against integrin a3 shows therapeutic potential for ovarian cancer. Cancer Sci 111:3478-3492 (2020). PubMed: 32648337