概述

  • 产品名称Anti-CANT1抗体
    参阅全部 CANT1 一抗
  • 描述
    兔多克隆抗体to CANT1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 324-373 (SPDFGDIAVS HVGAVVPTHG FSSFKFIPNT DDQIIVALKS EEDSGRVASY) of human CANT1 (NP_620148).

  • 阳性对照
    • Transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab84786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD) [MIM:251450]. A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.
  • 序列相似性Belongs to the apyrase family.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Processed form: Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apyrase antibody
    • Apyrase homolog antibody
    • Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase antibody
    • Calcium activated nucleotidase 1 antibody
    • CANT 1 antibody
    • CANT1 antibody
    • CANT1_HUMAN antibody
    • Putative MAPK activating protein PM09 antibody
    • Putative MAPK-activating protein PM09 antibody
    • Putative NF kappa B activating protein 107 antibody
    • Putative NF-kappa-B-activating protein 107 antibody
    • SCAN 1 antibody
    • SCAN-1 antibody
    • SHAPY antibody
    • Soluble Ca activated nucleotidase isozyme 1 antibody
    • Soluble calcium activated nucleotidase 1 antibody
    • Soluble calcium activated nucleotidase SCAN 1 antibody
    • Soluble calcium-activated nucleotidase 1 antibody
    see all

Anti-CANT1 antibody 图像

  • Anti-CANT1 antibody (ab84786) at 1 µg/ml (in 5% skim milk / PBS buffer) + transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 42 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 44 kDa. We are unsure as to the identity of these extra bands.

Anti-CANT1 antibody (ab84786)参考文献

ab84786 has not yet been referenced specifically in any publications.

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