Anti-Cannabinoid Receptor II抗体(ab123056)

概述

  • 产品名称Anti-Cannabinoid Receptor II抗体
    参阅全部 Cannabinoid Receptor II 一抗
  • 描述
    兔多克隆抗体to Cannabinoid Receptor II
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 293-342 (MVNPVIYALR SGEIRSSAHH CLAHWKKCVR GLGSEAKEEA PRSSVTETEA) of Human Cannabinoid Receptor II (NP_001832).

  • 阳性对照
    • 721_B cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Constituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab123056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
  • 组织特异性Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • 细胞定位Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cannabinoid receptor 2 antibody
    • Cannabinoid receptor 2 macrophage antibody
    • CB 2 antibody
    • CB-2 antibody
    • CB2 antibody
    • CNR2 antibody
    • CNR2_HUMAN antibody
    • CNRII antibody
    • CX 5 antibody
    • CX5 antibody
    • hCB2 antibody
    • testis-dominant CNR2 isoform CB2 antibody
    see all

Anti-Cannabinoid Receptor II antibody 图像

  • Anti-Cannabinoid Receptor II antibody (ab123056) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 40 kDa

Anti-Cannabinoid Receptor II antibody (ab123056)参考文献

ab123056 has not yet been referenced specifically in any publications.

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