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使用高引用率的试剂来研究细胞周期和癌症中的 Cdk-cyclin 复合物及其相关的蛋白靶标。
细胞分裂、细胞凋亡是癌症生物学的重点内容。细胞周期蛋白依赖性激酶(Cdk)与细胞周期蛋白结合,可形成 Cdk-cyclin 复合物,这种复合物在细胞周期进程中起到关键作用。
Cdk-cyclin 复合物可调节一系列活动,帮助细胞从静息态(G0)、生长期(G1)进入 DNA 复制期(S),最终到细胞分裂期(M)。任何阶段的细胞周期调控出现异常都会导致细胞周期停滞,并可能与癌症有关1。
目录
p21 直接与 Cdk-cyclin 复合物结合,确保 Cdk 处于失活状态2。失活 Cdk 不能将下游靶靶标磷酸化,从而导致细胞周期停滞3。
调节 p21 及其相关的 Cdk 靶蛋白会造成 DNA 损伤、复制应激、DNA 累积,最终导致癌变。研究细胞周期停滞期间的 DNA 变化,有助于表征细胞周期进程以及靶调节在癌症中的作用。
Type | Reagent name | Description | AbID |
Antibody | Anti-p21 antibody [ER362] | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IHC-P, Flow Cyt, ICC/IF, IP | ab109520 |
Anti-p21 antibody [CIP1/823] - BSA and Azide free | Type: Mouse monoclonal antibody Reactivity: Hu Applications: IHC-P, WB, ICC/IF, Flow Cyt | ab212247 |
作为 p21 的负调节因子,MDM2 的抑制作用会提高 p21 的水平,但 MDM2 的过表达则会起到相反的效果。MDM2 与 p21 结合,促使 p21 被蛋白酶体降解4。
Type | Reagent name | Description | AbID |
Antibody | Anti-MDM2 antibody | Type: Mouse monoclonal Reactivity: Hu, Mo Applications: Flow Cyt, ICC/IF, IHC-P, IHC-Fr, IP, WB, ICC | ab16895 |
Cdk 2 与多种癌症的肿瘤增殖有关。p21 与 Cdk2-cyclin E 复合物结合,在 G1/S 检查点阻滞细胞。因此,p21 抑制 Cdk2 对于 DNA 损伤修复至关重要5。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cdk2 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu, Mo, Rt Applications: ICC/IF, IP, WB, Flow Cyt, IHC-P | ab32147 |
Anti-CDK2 (phospho Y15) antibody | Type: Rabbit monoclonal antibody Reactivity: Hu, Mo, Rt Applications: IHC-P, WB, IP | ab76146 | |
Anti-CDK2 (phospho T14) antibody | Type: Rabbit monoclonal antibody Reactivity: Hu, Rt, ChHa Applications: WB, IP, IHC-P, ICC | ab68265 | |
Anti-CDK2 (phospho T160) antibody | Type: Rabbit monoclonal antibody Reactivity: Hu, Mo, Rt Applications: IHC-P, WB | ab194868 |
G2 期,clin B1 水平升高,促进 Cdk1-cyclin B1 复合物的形成6。Cdk1-cyclin B1 可由 Cdc25 磷酸酶激活7。Cyclin B1 通常在某些癌症类型中过表达。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cyclin B1 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IHC-P, Flow Cyt, ICC, IP | ab32053 |
Anti-Cyclin B1 (p S126) antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IP | ab133439 |
Cdk2-cyclin E1 复合物能够促进视网膜母细胞瘤蛋白(Rb)的磷酸化、E2F 转录因子的释放以及 DNA S 期的进入8。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cyclin E1 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, ICC/IF, Flow Cyt, IP | ab33911 |
Cyclin A1 在多种癌症中表达9。p53 激活 cyclin A1 启动子。Cdk2-cyclin A1 复合物可以修复双链断裂的 DNA10。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cyclin A1/A2 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IHC-P, IP | ab185619 |
Cdc25c
Cdc25 将 Cdk2 上的 Y15 和 T14 去磷酸化,这是 Cdk 活化/细胞周期进程中的限速步骤11。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cdc25C antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IHC-P, ICC/IF, Flow Cyt, IP | ab32444 |
CDC6 与多类癌症中的致癌活性有关12。在 G1 期,Cdc6 蛋白的表达增加。Cdc6 调节启动 DNA 复制,其表达水平通过 Cdk2-cyclin E 的活性调节保持稳定13。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cdc6 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: ICC/IF, WB, IHC-P, Flow Cyt | ab109315 |
Anti-Cdc6 (phospho S54) antibody | Phosphorylation on S54 prevents Cdc6 from APC/C-dependent proteolysis22. Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, ICC/IF, Dot blot | ab75809 | |
Anti-Cdc6 (phospho S106) antibody | Cdk2-Cyclin E phosphorylation site required to induce G2 arrest23. Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB | ab76422 | |
Anti-CRM1 antibody (Nuclear export factor) | CRM1 regulates Cyclin B1 nuclear export and localization10. Type: Rabbit monoclonal antibody Reactivity: Hu, Mo, Rt Applications: IHC-P, Flow Cyt, ICC/IF, WB | ab191081 |
Cdk4-cyclin D 复合物的激酶活性是高效细胞增殖的必备条件,在癌症形成过程中起到重要作用14,而 p21 浓度升高可抑制 Cdk4-cyclin D 复合物的激酶活性13。缺乏 Cdk4 和 Cdk6 时,Cyclin D2 可与 Cdk2 结合16。
Type | Reagent name | Description | AbID |
Antibody | Anti-Cdk4 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: WB, IHC-P, Flow Cyt, ICC/IF | ab108357 |
Anti-Cdk6 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: Flow Cyt, ICC/IF, IHC-P, WB | ab124821 | |
Anti-Cyclin D1 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu, Mo, Rt Applications: WB, IP, ICC/IF, IHC-P | ab134175 | |
Anti-Cyclin D2 antibody | Type: Rabbit monoclonal antibody Reactivity: Hu Applications: ICC/IF, IP, WB | ab207604 |
参考文献