Anti-cAMP抗体(ab832)

概述

  • 产品名称
  • 描述
    羊多克隆抗体to cAMP
  • 特异性
    This antibody reacts with cyclic AMP and to lesser degrees with other 5’ nucleotides.
  • 经测试应用
    适用于: ELISA, RIAmore details
  • 种属反应性
    与反应: Species independent
  • 免疫原

    Succinylated cAMP conjugated to bovine serum albumin.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    serum with 0.01% sodium azide
  • 纯度
    Whole antiserum
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
AP
ELISA
RIA
  • 应用说明
    This antibody may be used inradioimmunoassays to detect andquantitate cAMP; 50% binding is achieved with a 1:1,000 dilution. This antibody may also be used in ELISA and to affinity purify cAMP.
  • 靶标

    • 相关性
      Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery.
    • 细胞定位
      Secreted
    • 别名
      • 3' 5' cyclic adenosine monophosphate antibody
      • Cyclic adenosine monophosphate antibody
      • Cyclic AMP antibody

    Anti-cAMP antibody (ab832)参考文献

    ab832 has not yet been referenced specifically in any publications.

    Product Wall

    ab832 may cross-react with other 5'-nucleotides, however sufficient dilution can eliminate this cross-reactivity while retaining reactivity with cAMP. Working dilution should be optimized by the end user.

    Thank you for your enquiry. I have received replies from the four product originators. Here is the information that you requested for: ab12414 - First lots were sold in 1987 so before 2003. ab832 - Definitely before 2003. ab2345 - Not cert...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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