Anti-CaMKK抗体, prediluted (ab53902)

概述

  • 产品名称Anti-CaMKK抗体, prediluted
    参阅全部 CaMKK 一抗
  • 描述
    兔多克隆抗体to CaMKK, prediluted
  • 特异性This antibody reacts with CaMKK alpha.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    GEGGKSPELPGVQEDEAAS

    , corresponding to amino acids 487-505 of Human CaMKK alpha, [Swiss Prot Q8N5S9]

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab53902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use for 30 min at RT.
    Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
    • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
      Contains 1 protein kinase domain.
    • 结构域The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
      The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
    • 翻译后修饰Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Ca2+/calmodulin-dependent protein kinase kinase alpha antibody
      • Calcium/calmodulin dependent protein kinase kinase antibody
      • Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody
      • Calcium/calmodulin dependent protein kinase kinase 1 antibody
      • Calcium/calmodulin dependent protein kinase kinase alpha antibody
      • Calcium/calmodulin-dependent protein kinase kinase 1 antibody
      • Calcium/calmodulin-dependent protein kinase kinase alpha antibody
      • CaM kinase kinase alpha antibody
      • CaM-kinase IV kinase antibody
      • CaM-kinase kinase 1 antibody
      • CaM-kinase kinase alpha antibody
      • CaM-KK 1 antibody
      • CaM-KK alpha antibody
      • CaMKK 1 antibody
      • CaMKK alpha antibody
      • CAMKK alpha protein antibody
      • CaMKK antibody
      • Camkk1 antibody
      • CAMKKA antibody
      • DKFZp761M0423 antibody
      • KKCC1_HUMAN antibody
      • MGC34095 antibody
      • OTTMUSP00000006419 antibody
      see all

    Anti-CaMKK antibody, prediluted 图像

    • Human brain stained with neat ab53902

    Anti-CaMKK antibody, prediluted (ab53902)参考文献

    ab53902 has not yet been referenced specifically in any publications.

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