概述

  • 产品名称Anti-Calsequestrin 2抗体
    参阅全部 Calsequestrin 2 一抗
  • 描述
    兔多克隆抗体to Calsequestrin 2
  • 特异性This antibody reacts with Calsequestrin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Rabbit, Cow, Dog, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Mouse Calsequestrin 2 aa 57-74 conjugated to keyhole limpet haemocyanin.
    Sequence:

    LYYHEPVSSDKVSQKQFQLKE

  • 阳性对照
    • Extract of rat cardiac muscle (S1 fraction); HEK-293T cells

性能

应用

Our Abpromise guarantee covers the use of ab62662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).

Used at a concentration of 0.5 - 1.0 µg/ml using HEK-293T cells expressing human calsequestrin-2 and extract of rat cardiac muscle (S1 fraction). Staining of the calsequestrin-2 band is specifically inhibited by the immunizing peptide.

靶标

  • 功能Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
  • 疾病相关Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
  • 序列相似性Belongs to the calsequestrin family.
  • 细胞定位Sarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA033488 antibody
    • AW146219 antibody
    • Calsequestrin 2 (cardiac muscle) antibody
    • Calsequestrin 2 fast twitch cardiac muscle antibody
    • Calsequestrin antibody
    • Calsequestrin cardiac muscle isoform antibody
    • Calsequestrin fast twitch cardiac muscle antibody
    • Calsequestrin-2 antibody
    • Calsequestrin2 antibody
    • cardCSQ antibody
    • Cardiac calsequestrin 2 antibody
    • cardiac muscle isoform antibody
    • CASQ 2 antibody
    • CASQ2 antibody
    • CASQ2_HUMAN antibody
    • cCSQ antibody
    • ESTM52 antibody
    • FLJ26321 antibody
    • FLJ93514 antibody
    • PDIB2 antibody
    see all

Anti-Calsequestrin 2 antibody (ab62662)参考文献

This product has been referenced in:
  • Patel BB  et al. Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice. Toxicol Sci 133:174-85 (2013). Mouse . Read more (PubMed: 23418087) »
  • Calvé A  et al. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol 302:H2048-57 (2012). Read more (PubMed: 22447943) »

See all 2 Publications for this product

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