The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).
Used at a concentration of 0.5 - 1.0 µg/ml using HEK-293T cells expressing human calsequestrin-2 and extract of rat cardiac muscle (S1 fraction). Staining of the calsequestrin-2 band is specifically inhibited by the immunizing peptide.
功能Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium.
疾病相关Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:611938]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
序列相似性Belongs to the calsequestrin family.
细胞定位Sarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
Calsequestrin 2 fast twitch cardiac muscle antibody
Calsequestrin cardiac muscle isoform antibody
Calsequestrin fast twitch cardiac muscle antibody
Cardiac calsequestrin 2 antibody
cardiac muscle isoform antibody
CASQ 2 antibody
Anti-Calsequestrin 2 antibody (ab62662)参考文献
This product has been referenced in:
Patel BB et al. Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice. Toxicol Sci133:174-85 (2013).
Read more (PubMed: 23418087) »
Calvé A et al. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol302:H2048-57 (2012).
Read more (PubMed: 22447943) »