Anti-Calreticulin 3抗体(ab87139)


  • 产品名称Anti-Calreticulin 3抗体
    参阅全部 Calreticulin 3 一抗
  • 描述
    兔多克隆抗体to Calreticulin 3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (RWLQSTNDSR FGHFRLSSGK FYGHKEKDKG LQTTQNGRFY AISARFKPFS) of Human Calreticulin 3 (NP_659483).

  • 阳性对照
    • Jurkat cell lysate.



Our Abpromise guarantee covers the use of ab87139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • 功能During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
  • 组织特异性Testis specific.
  • 疾病相关Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the calreticulin family.
  • 结构域Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
    The interaction with glycans occurs through a binding site in the globular lectin domain.
    The zinc binding sites are localized to the N-domain.
  • 细胞定位Endoplasmic reticulum lumen.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CALR 3 antibody
    • CALR3 antibody
    • CALR3_HUMAN antibody
    • Calreticulin 2 antibody
    • Calreticulin-2 antibody
    • Calreticulin-3 antibody
    • Calreticulin2 antibody
    • Calreticulin3 antibody
    • Calsperin antibody
    • Cancer/testis antigen 93 antibody
    • CMH19 antibody
    • CRT2 antibody
    • CT93 antibody
    • FLJ25355 antibody
    • MGC26577 antibody
    see all

Anti-Calreticulin 3 antibody 图像

  • Anti-Calreticulin 3 antibody (ab87139) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)

Anti-Calreticulin 3 antibody (ab87139)参考文献

ab87139 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab87139.
Please use the links above to contact us or submit feedback about this product.