Anti-Calreticulin 3抗体(ab57346)


  • 产品名称Anti-Calreticulin 3抗体
    参阅全部 Calreticulin 3 一抗
  • 描述
    小鼠单克隆抗体to Calreticulin 3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 21-385 of Human Calreticulin 3



Our Abpromise guarantee covers the use of ab57346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
    • 组织特异性Testis specific.
    • 疾病相关Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19) [MIM:613875]. CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 序列相似性Belongs to the calreticulin family.
    • 结构域Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
      The interaction with glycans occurs through a binding site in the globular lectin domain.
      The zinc binding sites are localized to the N-domain.
    • 细胞定位Endoplasmic reticulum lumen.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CALR 3 antibody
      • CALR3 antibody
      • CALR3_HUMAN antibody
      • Calreticulin 2 antibody
      • Calreticulin-2 antibody
      • Calreticulin-3 antibody
      • Calreticulin2 antibody
      • Calreticulin3 antibody
      • Calsperin antibody
      • Cancer/testis antigen 93 antibody
      • CMH19 antibody
      • CRT2 antibody
      • CT93 antibody
      • FLJ25355 antibody
      • MGC26577 antibody
      see all

    Anti-Calreticulin 3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57346 Calreticulin 3 antibody at 1ug/ml. Predicted band size of immunogen is 66 kDa

    Anti-Calreticulin 3 antibody (ab57346)参考文献

    ab57346 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Human Cell lysate - whole cell (HUVEC)
    Loading amount 27 µg
    Specification HUVEC
    Gel Running Conditions Non-reduced Denaturing (7.5% Acrylamide)
    Blocking step Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

    Dr. Anna Armoza

    Verified customer

    提交于 Apr 12 2011