概述

  • 产品名称Anti-Calpain S1抗体
    参阅全部 Calpain S1 一抗
  • 描述
    小鼠单克隆抗体to Calpain S1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: KRWQAIYKQF DTDRSGTICS SELPGAFEAA GFHLNEHLYN MIIRRYSDES GNMDFDNFIS CLVRLDAMFR AFKSLDKDGT GQIQVNIQE, corresponding to amino acids 172-260 of Human Calpain S1

性能

应用

Our Abpromise guarantee covers the use of ab54929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    • 序列相似性Contains 5 EF-hand domains.
    • 结构域The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.
      EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.
    • 细胞定位Cytoplasm. Cell membrane. Translocates to the plasma membrane upon calcium binding.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 30K antibody
      • Calcium activated neutral proteinase antibody
      • Calcium activated neutral proteinase small subunit antibody
      • Calcium dependent protease small subunit 1 antibody
      • Calcium dependent protease small subunit antibody
      • Calcium-activated neutral proteinase small subunit antibody
      • Calcium-dependent protease small subunit 1 antibody
      • Calcium-dependent protease small subunit antibody
      • Calpain 4 antibody
      • Calpain 4 small subunit (30K) antibody
      • Calpain 4 small subunit antibody
      • Calpain regulatory subunit antibody
      • Calpain small polypeptide antibody
      • Calpain small subunit 1 antibody
      • Calpain4 antibody
      • CalpainS1 antibody
      • CANP antibody
      • CANP small subunit antibody
      • CANPS antibody
      • CAPN 4 antibody
      • CAPN S1 antibody
      • CAPN4 antibody
      • CAPNS 1 antibody
      • CAPNS antibody
      • Capns1 antibody
      • CDPS antibody
      • CPNS1_HUMAN antibody
      • CSS 1 antibody
      • CSS1 antibody
      see all

    Anti-Calpain S1 antibody 图像

    • Calpain S1 antibody (ab54929) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human kidney.


    • Predicted band size : 28 kDa
      Calpain S1 antibody (ab54929) at 1ug/lane + A-431 cell lysate at 25ug/lane.

    Anti-Calpain S1 antibody (ab54929)参考文献

    This product has been referenced in:
    • McHugh BJ  et al. Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. J Cell Sci 123:51-61 (2010). WB ; Human . Read more (PubMed: 20016066) »
    • Wiesen JL & Tomasi TB Dicer is regulated by cellular stresses and interferons. Mol Immunol 46:1222-8 (2009). Read more (PubMed: 19118902) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"