Anti-Calpain S1抗体[28F3] (Biotin) (ab78565)

概述

  • 产品名称Anti-Calpain S1抗体[28F3] (Biotin)
    参阅全部 Calpain S1 一抗
  • 描述
    小鼠单克隆抗体[28F3] to Calpain S1 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Cow, Human
    不与反应: Mouse, Rat
  • 免疫原

    Human calpain from placenta

  • 阳性对照
    • Normal human fibroblast; A431 and Madin-Darby bovine kidney cells (MDBK) lysates.
  • 常规说明This product was used in Hornberger W et al.,(2012) Novel approaches in label-free kinetic detection of small molecule ligand binding to receptor proteins using SAW (surface acoustic wave) technology. Poster Presented at Miptec Congress 2012

性能

应用

Our Abpromise guarantee covers the use of ab78565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa).
IP Use at an assay dependent dilution.

靶标

  • 功能Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 序列相似性Contains 5 EF-hand domains.
  • 结构域The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.
    EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.
  • 细胞定位Cytoplasm. Cell membrane. Translocates to the plasma membrane upon calcium binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 30K antibody
    • Calcium activated neutral proteinase antibody
    • Calcium activated neutral proteinase small subunit antibody
    • Calcium dependent protease small subunit 1 antibody
    • Calcium dependent protease small subunit antibody
    • Calcium-activated neutral proteinase small subunit antibody
    • Calcium-dependent protease small subunit 1 antibody
    • Calcium-dependent protease small subunit antibody
    • Calpain 4 antibody
    • Calpain 4 small subunit (30K) antibody
    • Calpain 4 small subunit antibody
    • Calpain regulatory subunit antibody
    • Calpain small polypeptide antibody
    • Calpain small subunit 1 antibody
    • Calpain4 antibody
    • CalpainS1 antibody
    • CANP antibody
    • CANP small subunit antibody
    • CANPS antibody
    • CAPN 4 antibody
    • CAPN S1 antibody
    • CAPN4 antibody
    • CAPNS 1 antibody
    • CAPNS antibody
    • Capns1 antibody
    • CDPS antibody
    • CPNS1_HUMAN antibody
    • CSS 1 antibody
    • CSS1 antibody
    see all

Anti-Calpain S1 antibody [28F3] (Biotin) (ab78565)参考文献

ab78565 has not yet been referenced specifically in any publications.

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