概述

  • 产品名称Anti-Calpain 10抗体
    参阅全部 Calpain 10 一抗
  • 描述
    兔多克隆抗体to Calpain 10
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (RAGRGATPAR ELFRDAAFPA ADSSLFCDLS TPLAQFREDI TWRRPQEICA) of Human Calpain 10 (NP_075573).

  • 阳性对照
    • HT1080 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab87206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 组织特异性Ubiquitous.
  • 疾病相关Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1) [MIM:601283]. It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • 序列相似性Belongs to the peptidase C2 family.
    Contains 1 calpain catalytic domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Calcium activated neutral protease antibody
    • Calcium activated neutral proteinase 10 antibody
    • Calcium-activated neutral proteinase 10 antibody
    • calpain like protease CAPN10 antibody
    • Calpain-10 antibody
    • Calpain10 antibody
    • CAN10_HUMAN antibody
    • CANP 10 antibody
    • CANP10 antibody
    • CAPN 10 antibody
    • CAPN10 antibody
    • EC 3.4.22. antibody
    • KIAA1845 antibody
    • NIDDM1 antibody
    see all

Anti-Calpain 10 antibody 图像

  • Anti-Calpain 10 antibody (ab87206) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 58 kDa
    Observed band size : 58 kDa
    Additional bands at : 80 kDa,90 kDa. We are unsure as to the identity of these extra bands.

Anti-Calpain 10 antibody (ab87206)参考文献

ab87206 has not yet been referenced specifically in any publications.

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