Anti-CAD (phospho T456)抗体(ab111837)

概述

  • 产品名称Anti-CAD (phospho T456)抗体
    参阅全部 CAD 一抗
  • 描述
    兔多克隆抗体to CAD (phospho T456)
  • 特异性ab111837 detects endogenous levels of CAD only when phosphorylated at threonine 456.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from Human CAD around the phosphorylation site of threonine 456 (P-I-TP-P-H).

  • 阳性对照
    • Human colon carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
  • 细胞定位Cytoplasmic and Nuclear
  • 数据库链接
  • 别名
    • Aspartate carbamoyltransferase antibody
    • Aspartate transcarbamylase antibody
    • CAD protein antibody
    • CAD trifunctional protein antibody
    • Carbamoyl phosphate synthetase 2 antibody
    • CPSase ATCase DHOase antibody
    • Dihydroorotase antibody
    • Glutamine dependent carbamoyl phosphate synthase antibody
    • Multifunctional protein CAD antibody
    see all

Anti-CAD (phospho T456) antibody 图像

  • ab111837 at 1/50 dilution staining CAD in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-CAD (phospho T456) antibody (ab111837)参考文献

ab111837 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111837.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"