概述

  • 产品名称Anti-CAD抗体
    参阅全部 CAD 一抗
  • 描述
    兔多克隆抗体to CAD
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Guinea pig, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within residues 1650 - 1700 of Human CAD (NP_004332.2)

  • 阳性对照
    • Breast carcinoma, colon carcinoma, linitis plastica stomach cancer, ovarian carcinoma, stomach adenocarcinoma, testicular seminoma.

性能

应用

Our Abpromise guarantee covers the use of ab84474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Carbamoyl phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD) is a multifunctional protein that initiates and regulates mammalian de novo pyrimidine biosynthesis. This trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis is the rate-limiting step in the de novo pyrimidine synthetic pathway. Although most of the CAD protein in the cell is cytosolic, phosphorylation at threonine 456 localizes the protein to the nucleus. While MAPK and EGF phosphorylate CAD at threonine 456, MAPK and c-myc have been found to induce over-expression of CAD.
    • 细胞定位Cytoplasmic and Nuclear
    • 数据库链接
    • 别名
      • Aspartate carbamoyltransferase antibody
      • Aspartate transcarbamylase antibody
      • CAD protein antibody
      • CAD trifunctional protein antibody
      • Carbamoyl phosphate synthetase 2 antibody
      • CPSase ATCase DHOase antibody
      • Dihydroorotase antibody
      • Glutamine dependent carbamoyl phosphate synthase antibody
      • Multifunctional protein CAD antibody
      see all

    Anti-CAD antibody 图像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon carcinoma, using 1/250 ab84474 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human mucinous ovarian carcinoma, using 1/250 ab84474 followed by DAB staining.

    Anti-CAD antibody (ab84474)参考文献

    ab84474 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84474.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"