概述

  • 产品名称
  • 描述
    山羊多克隆抗体to CACNB4
  • 特异性
    This antibody is expected to recognise all reported protein isoforms of human CACNB4.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Pig
  • 免疫原

    Synthetic peptide:

    SPGGYSHDSRHRL

    , corresponding to C terminal amino acids 508-520 of Human CACNB4

  • 阳性对照
    • Lysates prepared from human bone marrow. Lysates prepared from transfected HEK293 transiently expressing CACNB4.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    This antibody has been purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab26060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 59 kDa).

靶标

  • 功能
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 组织特异性
    Expressed predominantly in the cerebellum and kidney.
  • 疾病相关
    Genetic variations in CACNB4 are the cause of susceptibility to idiopathic generalized epilepsy type 9 (IGE9) [MIM:607682]. IGE9 is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
    Genetic variations in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6) [MIM:607682]. EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
  • 序列相似性
    Belongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAB4 antibody
    • CACB4_HUMAN antibody
    • Cacnb4 antibody
    • CACNLB4 antibody
    • Calcium channel voltage dependent beta 4 subunit antibody
    • Calcium channel voltage dependent subunit beta 4 antibody
    • Calcium channel voltage-dependent subunit beta 4 antibody
    • Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody
    • EA5 antibody
    • EIG9 antibody
    • EJM antibody
    • EJM4 antibody
    • EJM6 antibody
    • Voltage-dependent L-type calcium channel subunit beta-4 antibody
    see all

图片

实验方案

文献

This product has been referenced in:
  • Mehmood T  et al. Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome. Hum Genet 129:255-69 (2011). WB ; Mouse . Read more (PubMed: 21116650) »

See 1 Publication for this product

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