The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 74 kDa.
1/500. Has not been tested in ELISA on endogenous samples.
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Expressed in all tissues.
Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4) [MIM:611876]. BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain.
Rougier JS et al. Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote a2d-1-induced downregulation of Ca v1.2 channels. Pflugers ArchN/A:N/A (2014).
Read more (PubMed: 25366495) »
Rougier JS et al. Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly-synthesized Cav1.2 calcium channels. J Biol Chem : (2011).
Read more (PubMed: 21220429) »