Anti-CACNA2D2抗体(ab88486)

概述

  • 产品名称Anti-CACNA2D2抗体
    参阅全部 CACNA2D2 一抗
  • 描述
    小鼠单克隆抗体to CACNA2D2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Rhesus monkey
  • 免疫原

    Recombinant fragment corresponding to the internal amino acids 65-163 (PQQHTMQHWA RRLEQEVDGV MRIFGGVQQL REIYKDNRNL FEVQENEPQK LVEKVAGDIE SLLDRKVQAL KRLADAAENF QKAHRWQDNI KEEDIVYY*) of Human CACNA2D2 (NP_006021) linked to a proprietary tag.

  • 阳性对照
    • HeLa cell lysate

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab88486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 130 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
  • 组织特异性Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
  • 序列相似性Belongs to the calcium channel subunit alpha-2/delta family.
    Contains 1 cache domain.
    Contains 1 VWFA domain.
  • 结构域The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.
  • 翻译后修饰May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
  • 细胞定位Membrane. Colocalizes with CACNA1A in lipid raft fractions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha 2 delta calcium channel subunit antibody
    • CA2D2_HUMAN antibody
    • CACNA2D antibody
    • Cacna2d2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody
    • Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody
    • Gene 26 antibody
    • KIAA0558 antibody
    • LUAC11.1 antibody
    • Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody
    • Voltage-dependent calcium channel subunit delta-2 antibody
    • Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
    see all

Anti-CACNA2D2 antibody 图像

Anti-CACNA2D2 antibody (ab88486)参考文献

ab88486 has not yet been referenced specifically in any publications.

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Thank you for contacting us. Epitope mapping has not been performed for the monoclonal antibodies ab2864 and ab88486. The other antibodies are polyclonals and will bind at many different sites of the protein. Please let me know if I can be of further a...

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