概述

  • 产品名称Anti-CACNA1I抗体
  • 描述
    小鼠单克隆抗体to CACNA1I
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: GLLRNRCFLE ENFTIQGDVA LPPYYQPEED DEMPFICSLS GDNGIMGCHE IPPLKEQGRE CCLSKDDVYD FGAGRQDLNA SGLCVNWNRY YNVCRTGSA, corresponding to amino acids 233-332 of Human CACNA1I

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Calcium channel CaV3.3 (a1I) is a low-voltage-activated T-type calcium channel. Such T-type channels are expressed throughout the body. In heart, they may be involved in pacemaker current. In neurons, too, these channels may play a secondary pacemaker role. Three genes encoding T-type Ca2+ channels have been cloned and designated as CaV3.1 (a1G), CaV3.2 (a1H) and CaV3.3 (a1I). While CaV3.1 (a 1G) and CaV3.2 (a1H) are widely expressed in various tissues, CaV3.3 (a1I) is primarily expressed in the central nervous system, where high expression was described in thalamic neurons. The Ca2+ current generated by the CaV3.3 channel displays much slower activation and inactivation compared to the currents produced by CaV3.1 and CaV3.2, suggesting it might play a different role in neuronal excitability.
    • 细胞定位Membrane; multi-pass membrane protein.
    • 数据库链接
    • 别名
      • calcium channel, voltage-dependent, alpha 1I subunit antibody
      • cav 3.3 antibody
      • cav3.3 antibody
      • KIAA1120 antibody

    Anti-CACNA1I antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56439 CACNA1I antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-CACNA1I antibody (ab56439)参考文献

    ab56439 has not yet been referenced specifically in any publications.

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