Anti-CACNA1C抗体(ab140760)
Key features and details
- Rabbit polyclonal to CACNA1C
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CACNA1C抗体
参阅全部 CACNA1C 一抗 -
描述
兔多克隆抗体to CACNA1C -
宿主
Rabbit -
特异性
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Monkey, Gorilla, Common marmoset -
免疫原
Synthetic peptide corresponding to Human CACNA1C (internal sequence). Synthetic 16 amino acid peptide from internal region of human CACNA1C
Database link: Q13936 -
阳性对照
- Human small intestine tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. -
存储溶液
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab140760于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
靶标
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功能
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. -
组织特异性
Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. -
疾病相关
Timothy syndrome
Brugada syndrome 3 -
序列相似性
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. -
结构域
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel. -
翻译后修饰
Phosphorylation by PKA activates the channel. -
细胞定位
Membrane. Cell membrane. The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 100406735 Common marmoset
- Entrez Gene: 775 Human
- Omim: 114205 Human
- SwissProt: Q13936 Human
- Unigene: 118262 Human
- Unigene: 690010 Human
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别名
- alpha-1 polypeptide antibody
- cardiac muscle antibody
- isoform 1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab140760 尚未被引用在任何文献中。