概述

  • 产品名称Cabergoline
  • 描述
    D2-like receptor agonist
  • 生物学描述D2-like receptor agonist (Ki values are 0.7 (D2), 1.5 (D3), 9.0 (D4) and 165 nM (D5)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT1A), 8.7 (5-HT1D), 6.2 (5-HT2A) and 1.2 nM (5-HT2B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
  • 纯度> 99%

性能

    应用

    Our Abpromise guarantee covers the use of ab120564 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Cabergoline 图像

    • PC12 cells were incubated at 37ºC for 30 minutes with vehicle control (0 µM) and different concentrations of cabergoline (ab120564). Increased expression of AKT1 (phospho S473) (ab66138) in PC12 cells correlates with an increase in cabergoline concentration, as described in literature.

      Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab66138 at 1/1000 dilution and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.

    Cabergoline (ab120564)参考文献

    This product has been referenced in:
    • Chiba S  et al. Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling. Psychopharmacology (Berl) 211:291-301 (2010). Read more (PubMed: 20526584) »
    • Kvernmo T  et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther 28:1065-78 (2006). Read more (PubMed: 16982285) »
    • Eguchi K  et al. In vivo effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors. Endocr J 42:153-61 (1995). Read more (PubMed: 7627259) »

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