概述

  • 产品名称
  • 描述
    兔多克隆抗体to C9
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human C9 protein.

  • 阳性对照
    • Human Small Intestine, Vessels Human Placenta methanol-fixed HepG2 Raji cell lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, Tris glycine
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab118902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 62 kDa.
IHC-P Use a concentration of 10 µg/ml.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
  • 组织特异性
    Plasma.
  • 疾病相关
    Defects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • 序列相似性
    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 1 TSP type-1 domain.
  • 翻译后修饰
    Thrombin cleaves factor C9 to produce C9a and C9b.
    Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位
    Secreted. Cell membrane. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARMD15 antibody
    • C9 antibody
    • C9 deficiency antibody
    • C9 deficiency with dermatomyositis antibody
    • C9D antibody
    • CO9_HUMAN antibody
    • Complement component 9 antibody
    • Complement component 9 deficiency antibody
    • Complement component C9 antibody
    • Complement component C9b antibody
    see all

Anti-C9 antibody 图像

  • Immunohistochemistry analysis (Formalin-Fixed, Paraffin-Embedded) of Human Small Intestine, Vessels stained with ab118902 at 10 µg/ml
  • Immunohistochemistry analysis (Formalin-Fixed, Paraffin-Embedded) of Human Placenta stained with ab118902 at 10 µg/ml
  • Immunofluorescence analysis of methanol-fixed HepG2, using ab118902 at 1:200 dilution.
  • Anti-C9 antibody (ab118902) at 1/500 dilution + Raji cell lysate at 30 µg

    Predicted band size : 62 kDa

Anti-C9 antibody (ab118902)参考文献

ab118902 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118902.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册