Anti-C8抗体[056B-373] (ab59140)

概述

  • 产品名称Anti-C8抗体[056B-373]
  • 描述
    小鼠单克隆抗体[056B-373] to C8
  • 经测试应用适用于: WB, ELISA, IHC-Fr, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified human C8

  • 阳性对照
    • Kidney from post streptoccal glomerulonephritis patients.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.1% Sodium azide
    Constituent: 99% Borate buffered saline
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号056B-373
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 151 kDa.
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性C8 is synthesised in the liver, monocytes and fibroblasts and is a plasma protein consisting of three non identical polypeptide chains. The alpha-chain (64kDa) and gamma chain (22kDa) are disulphide linked, these associate non-covalently with the beta-chain (64kDa), to form the native C8 molecule with a molecular weight of 151kDa. Normal plasma concentration is 80mg/L. C8 is one of the terminal proteins of the complement pathways. C8 binds to the membrane bound C5b-7, C5b-8 combines with C9 to form the membrane attack complex (MAC). The MAC forms a hydrophilic, protein walled, transmembrane channel, formation of which leads to cell lysis and destruction.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • C8A antibody
    • C8B antibody
    • C8G antibody
    • Complement component 8 subunit alpha antibody
    • Complement component 8 subunit beta antibody
    • complement component 8, alpha polypeptide antibody
    • complement component 8, beta polypeptide antibody
    • complement component 8, gamma polypeptide antibody
    • Complement component C8 alpha chain antibody
    • Complement component C8 beta chain antibody
    • Complement component C8 gamma chain antibody
    • MGC142186 antibody
    • MGC163447 antibody
    see all

Anti-C8 antibody [056B-373] (ab59140)参考文献

ab59140 has not yet been referenced specifically in any publications.

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