概述

  • 产品名称
    Anti-C6orf150抗体
    参阅全部 C6orf150 一抗
  • 描述
    兔多克隆抗体to C6orf150
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 273-303 of Human C6orf150 (NP_612450.2)

  • 阳性对照
    • MDA-MB231 cell line lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab106985 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.

靶标

  • 功能
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
  • 组织特异性
    Expressed in the monocytic cell line THP1.
  • 序列相似性
    Belongs to the mab-21 family.
  • 细胞定位
    Cytoplasm > cytosol.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C6orf150 antibody
    • cGAMP synthase antibody
    • cGAS antibody
    • CGAS_HUMAN antibody
    • cGMP Synthase antibody
    • Chromosome 6 open reading frame 150 antibody
    • Cyclic GMP-AMP synthase antibody
    • h-cGAS antibody
    • Hypothetical protein LOC115004 antibody
    • Mab 21 domain containing 1 antibody
    • Mab-21 domain-containing protein 1 antibody
    • MB21D1 antibody
    • MGC131892 antibody
    • MGC142166 antibody
    • MGC142168 antibody
    • OTTHUMP00000016743 antibody
    • OTTHUMP00000039330 antibody
    • protein MB21D1 antibody
    • Uncharacterized protein C6orf150 antibody
    see all

Anti-C6orf150 antibody 图像

  • Anti-C6orf150 antibody (ab106985) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

    Predicted band size : 59 kDa

实验方案

Anti-C6orf150 antibody (ab106985)参考文献

ab106985 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106985.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册