概述

  • 产品名称Anti-C6orf150抗体
    参阅全部 C6orf150 一抗
  • 描述
    兔多克隆抗体to C6orf150
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 273-303 of Human C6orf150 (NP_612450.2)

  • 阳性对照
    • MDA-MB231 cell line lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab106985 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab106985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 59 kDa.

靶标

  • 功能Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
  • 组织特异性Expressed in the monocytic cell line THP1.
  • 序列相似性Belongs to the mab-21 family.
  • 细胞定位Cytoplasm > cytosol.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C6orf150 antibody
    • cGAMP synthase antibody
    • cGAS antibody
    • CGAS_HUMAN antibody
    • cGMP Synthase antibody
    • Chromosome 6 open reading frame 150 antibody
    • Cyclic GMP-AMP synthase antibody
    • h-cGAS antibody
    • Hypothetical protein LOC115004 antibody
    • Mab 21 domain containing 1 antibody
    • Mab-21 domain-containing protein 1 antibody
    • MB21D1 antibody
    • MGC131892 antibody
    • MGC142166 antibody
    • MGC142168 antibody
    • OTTHUMP00000016743 antibody
    • OTTHUMP00000039330 antibody
    • protein MB21D1 antibody
    • Uncharacterized protein C6orf150 antibody
    see all

Anti-C6orf150 antibody 图像

  • Anti-C6orf150 antibody (ab106985) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

    Predicted band size : 59 kDa

Anti-C6orf150 antibody (ab106985)参考文献

ab106985 has not yet been referenced specifically in any publications.

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