概述

  • 产品名称
    Anti-C6抗体[8G7]
    参阅全部 C6 一抗
  • 描述
    小鼠单克隆抗体[8G7] to C6
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    C6 protein purified from human plasma.

  • 阳性对照
    • Human plasma

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.03% Sodium Azide
    Constituents: 50% Glycerol, 0.01% BSA, HEPES, 0.15M Sodium chloride
  • Concentration information loading...
  • 克隆
    单克隆
  • 克隆编号
    8G7
  • 同种型
    IgG1
  • 轻链类型
    kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab71941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/5000. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).

靶标

  • 功能
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
  • 疾病相关
    Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • 序列相似性
    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 2 Kazal-like domains.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 Sushi (CCP/SCR) domains.
    Contains 3 TSP type-1 domains.
  • 翻译后修饰
    All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AW111623 antibody
    • C6 antibody
    • CO6_HUMAN antibody
    • Complement component 6 antibody
    • Complement component C6 antibody
    see all

Anti-C6 antibody [8G7] 图像

  • All lanes : Anti-C6 antibody [8G7] (ab71941) at 1/5000 dilution

    Lane 1 : C6 protein isolated from human plasma
    Lane 2 : Human plasma at 0.5 µl


    Predicted band size : 105 kDa
    Observed band size : 105 kDa
    Additional bands at : 62 kDa. We are unsure as to the identity of these extra bands.

实验方案

Anti-C6 antibody [8G7] (ab71941)参考文献

ab71941 has not yet been referenced specifically in any publications.

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