概述

  • 产品名称
  • 描述
    兔多克隆抗体to C5
  • 经测试应用
    适用于: IHC-FoFr, WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse
    不与反应: Human
  • 免疫原

    Recombinant protein from E.coli. The exact sequence information is considered to be commercially sensitive.

  • 阳性对照
    • liver tissues (hepatocytes)

性能

应用

Our Abpromise guarantee covers the use of ab11898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-FoFr Use at an assay dependent concentration. PubMed: 19541934
WB 1/10. Predicted molecular weight: 188.9 kDa.
IHC-Fr 1/10.

靶标

  • 功能
    Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
    Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
  • 疾病相关
    Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
    Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
  • 序列相似性
    Contains 1 anaphylatoxin-like domain.
    Contains 1 NTR domain.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anaphylatoxin C5a analog antibody
    • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
    • C5 antibody
    • C5a anaphylatoxin antibody
    • C5a antibody
    • C5b antibody
    • CO5_HUMAN antibody
    • Complement C5 alpha'' chain antibody
    • Complement C5 antibody
    • Complement component C5 antibody
    • CPAMD4 antibody
    • prepro-C5 antibody
    see all

文献

This product has been referenced in:
  • Lundh von Leithner P  et al. Complement factor h is critical in the maintenance of retinal perfusion. Am J Pathol 175:412-21 (2009). IHC-FoFr ; Mouse . Read more (PubMed: 19541934) »

See 1 Publication for this product

客户评价及客户问答

Thank you for contacting us.

The C5 antibody ab11898 has not, to our knowledge, been tested in a neutralization assay.

The antibody is purified over a protein G column to separate immunoglobulin from other proteins.

I h...

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Thank you very much for your reply, and I apologize that I did not mention the details of ab11898.

This antibody has not been tested in our labs in IHC or for reactivity with the mouse protein, so we do not have a specific dilution or concent...

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Thank you for your enquiry. For ab11898, the antibody should recognize the whole mouse C5 chain; since this is a polyclonal antibody it is very likely that it recognizes both C5a and C5b. As the sequence of the immunogen used is commercially sensitive,...

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Thank you for your questions regarding ab11898. This antibody does not cross react with human C5. The polyclonal antibody was generated with recombinant human protein from E.coli. In our product range we have the following antibodies which cross ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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