Anti-C5抗体[12F3] (ab17457)

概述

  • 产品名称Anti-C5抗体[12F3]
    参阅全部 C5 一抗
  • 描述
    小鼠单克隆抗体[12F3] to C5
  • 特异性ab17457 reacts with C5 in normal human plasma and no reaction is seen with plasma from C5 deficient patients.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native C5 protein isolated from human plasma.

  • 表位Epitope specificity differs from that of ab17930 but slightly overlaps, as determined by inhibition ELISA.

性能

应用

Our Abpromise guarantee covers the use of ab17457 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: 1/6000.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 190 kDa. ab17457 recognises C5 in non reduced form only by western blot.


    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
      Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
    • 疾病相关Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
      Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
    • 序列相似性Contains 1 anaphylatoxin-like domain.
      Contains 1 NTR domain.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Anaphylatoxin C5a analog antibody
      • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody
      • C5 antibody
      • C5a anaphylatoxin antibody
      • C5a antibody
      • C5b antibody
      • CO5_HUMAN antibody
      • Complement C5 alpha'' chain antibody
      • Complement C5 antibody
      • Complement component C5 antibody
      • CPAMD4 antibody
      • prepro-C5 antibody
      see all

    Anti-C5 antibody [12F3] (ab17457)参考文献

    ab17457 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. For ab11898, the antibody should recognize the whole mouse C5 chain; since this is a polyclonal antibody it is very likely that it recognizes both C5a and C5b. As the sequence of the immunogen used is commercially sensitive,...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"