Anti-C4c+C4b抗体(FITC) (ab4216)

概述

  • 产品名称Anti-C4c+C4b抗体(FITC)
  • 描述
    兔多克隆抗体to C4c+C4b (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope.
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    C4c complement isolated from complement activated human serum.

  • 常规说明

    Fluorescein isothiocyanate (FITC) isomer 1.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS
  • Concentration information loading...
  • 纯度IgG fraction
  • 纯化说明Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab4216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr
  • 应用说明Immunofluorescence: 1/50 - 1/100 for 30 - 60 mins at RT.
    Not tested in other applications.

    Optimal dilutions / concentrations should be determined by the end user.
  • 靶标

    • 相关性C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.
    • 细胞定位Secreted
    • 数据库链接
    • 别名
      • Acidic complement C4 antibody
      • Basic complement C4 antibody
      • CH antibody
      • Chido blood group antibody
      • Complement component 4A antibody
      • Complement component 4B antibody
      • RG antibody
      • Rodgers blood group antibody
      see all

    Anti-C4c+C4b antibody (FITC) (ab4216)参考文献

    ab4216 has not yet been referenced specifically in any publications.

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