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Human C4BP purified from plasma and shown to be homogeneous by SDS-PAGE.
C4-binding protein (C4BP) is a multimeric protein, synthesised in the liver. The most abundant form consists of seven alpha-chains (70kDa) and one beta-chain (45kDa) all linked by disulphide bonds to form the native protein with a molecular weight of 570kDa. It is is a plasma protein with a concentration of about 150mg/L in normal plasma. It is a component of the classical complement pathway. C4BP down regulates complement activity in two ways, it binds to C4b thus inhibiting the formation of C3-convertase (C4bC3a) and it accelerates the decay of existing convertases. C4BP acts as a cofactor in Factor I mediated C4b proteolysis. C4BP may also have a regulatory role in the coagulation system, by binding to Protein S. When bound toC4BP, Protein S is inactive.
Our Abpromise guarantee covers the use of ab8788 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration. ab37385-Sheep polyclonal IgG, is suitable for use as an isotype control with this antibody.|
|Double Immunodiffusion||Use at an assay dependent concentration.|
|Immunoelectrophoresis||Use at an assay dependent concentration.|
|Other||Use at an assay dependent concentration.|
Image from Pham CT et al, J Biol Chem. 2011 Jan 7;286(1):123-30. Epub 2010 Nov 3, Fig 8. DOI 10.1074/jbc.M110.180760
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