The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Predicted molecular weight: 68 kDa.
功能Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
组织特异性Highly expressed in testis and at lower levels in the submandibular salivary gland.
Western Blot analysis of an E. coli derived fusion protein (C3IP1 N-205 fusion protein) using ab14233 at a 1/2000 dilution.
Anti-C3IP1 antibody (ab14233)参考文献
This product has been referenced in:
Angers S et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol8:348-57 (2006).
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