概述

  • 产品名称Anti-C2ORF25抗体
    参阅全部 C2ORF25 一抗
  • 描述
    兔多克隆抗体to C2ORF25
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 215-264 (RAEGYWADFI DPSSGLAFFG PYTNNTLFET DERYRHLGFS VDDLGCCKVI) of Human C2ORF25 (NP_056517)

  • 阳性对照
    • human Fetal muscle lysate.

性能

应用

Our Abpromise guarantee covers the use of ab83554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/62500.

WB Use a concentration of 1 µg/ml. Detects a band of approximately 39, 50 kDa (predicted molecular weight: 33 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Involved in cobalamin metabolism.
  • 组织特异性Widely expressed at high levels.
  • 疾病相关Defects in MMADHC are the cause of methylmalonic aciduria and homocystinuria type cblD (MMAHCD) [MIM:277410]. A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Clinical features include developmental delay, hyotonia, mental retardation, seizures, megaloblastic anemia. Some patients manifest combined methylmalonic aciduria and homocystinuria (referred to as cblD original), some have only isolated homocystinuria (cblD variant 1), and others have only methylmalonic aciduria (cblD variant 2).
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C2orf25 antibody
    • cblD antibody
    • Chromosome 2 open reading frame 25 antibody
    • CL25022 antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria antibody
    • Methylmalonic aciduria and homocystinuria type D protein antibody
    • methylmalonic aciduria and homocystinuria type D protein, mitochondrial antibody
    • mitochondrial antibody
    • MMAD_HUMAN antibody
    • Mmadhc antibody
    • Protein C2orf25, mitochondrial antibody
    see all

Anti-C2ORF25 antibody 图像

  • Anti-C2ORF25 antibody (ab83554) at 1 µg/ml + fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa
    Observed band size : 39,50 kDa (why is the actual band size different from the predicted?)

Anti-C2ORF25 antibody (ab83554)参考文献

ab83554 has not yet been referenced specifically in any publications.

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