概述

  • 产品名称Anti-C20orf77抗体
    参阅全部 C20orf77 一抗
  • 描述
    兔多克隆抗体to C20orf77
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 143-192 (KKSLKRTFQQ IQEEEDDDYP GSYSPQDPSA GPLLTEELIK ALQDLENAAS) of Human C20orf77 (NP_067038).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab104222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性C20orf77 interacts with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. It is a transcriptional regulator which enhances expression of CCND1. It promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. It also revents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • C20orf77 antibody
    • Cell cycle related and expression elevated protein in tumor antibody
    • Chromosome 20 open reading frame 77 antibody
    • CREPT antibody
    • dJ1057B20.2 antibody
    • DKFZp434P0735 antibody
    • FLJ44520 antibody
    • Hypothetical protein LOC58490 antibody
    • NET60 antibody
    • Regulation of nuclear pre mRNA domain containing 1B antibody
    • Regulation of nuclear pre mRNA domain containing protein 1B antibody
    • Uncharacterized protein C20orf77 antibody
    see all

Anti-C20orf77 antibody 图像

  • Anti-C20orf77 antibody (ab104222) at 1 µg/ml (Anti-RPRD1B Antibody) + Jurkat cell lysate

    Predicted band size : 37 kDa

Anti-C20orf77 antibody (ab104222)参考文献

ab104222 has not yet been referenced specifically in any publications.

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