RabMAb

Anti-C1QC抗体[EPR2984Y] (ab75756)

概述

  • 产品名称Anti-C1QC抗体[EPR2984Y]
    参阅全部 C1QC 一抗
  • 描述
    兔单克隆抗体[EPR2984Y] to C1QC
  • 经测试应用适用于: WB, IP, IHC-P, ICC, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in human C1q (subunit C)

  • 阳性对照
    • Human plasma lysate and human liver tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab75756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 26 kDa (predicted molecular weight: 26 kDa).
IP 1/10.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC 1/250 - 1/500.
Flow Cyt 1/50.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

靶标

  • 功能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 疾病相关Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • 序列相似性Contains 1 C1q domain.
    Contains 1 collagen-like domain.
  • 翻译后修饰O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI385742 antibody
    • C1Q C antibody
    • C1qc antibody
    • C1QC_HUMAN antibody
    • C1QG antibody
    • Complement C1q subcomponent subunit C antibody
    • Complement component 1, q subcomponent, C chain antibody
    • complement component 1, q subcomponent, gamma polypeptide antibody
    see all

Anti-C1QC antibody [EPR2984Y] 图像

  • ab75756 at 1/100 dilution staining C1q in human liver by Immunohistochemistry, Paraffin-embedded tissue.
  • Anti-C1QC antibody [EPR2984Y] (ab75756) at 1/1000 dilution + human plasma lysate at 10 µg

    Secondary
    goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size : 26 kDa
    Observed band size : 26 kDa

Anti-C1QC antibody [EPR2984Y] (ab75756)参考文献

ab75756 has not yet been referenced specifically in any publications.

Product Wall

The Anti-C1QC antibody [EPR2984Y] (ab75756) is a tissue culture supernatant antibody. I can confirm that tissue culture tissue supernatant contains not only the pure antibody, but also other proteins and we do not regularly determine those concentratio...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"