概述

  • 产品名称Anti-C1QC抗体
    参阅全部 C1QC 一抗
  • 描述
    兔多克隆抗体to C1QC
  • 特异性detects endogenous levels of total C1QC protein.
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from internal sequence of Human C1QC (UniProt ID: P02747).

  • 阳性对照
    • Rat lung cell lysate, Human lung carcinoma tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab92689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
IHC-P
  • 应用说明ELISA: 1/40000.
    IHC-P: 1/50 - 1/100. Antigen retrieval is not essential but may optimise staining.
    WB: 1/500 - 1/1000. Predicted molecular weight: 26 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    • 疾病相关Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • 序列相似性Contains 1 C1q domain.
      Contains 1 collagen-like domain.
    • 翻译后修饰O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AI385742 antibody
      • C1Q C antibody
      • C1qc antibody
      • C1QC_HUMAN antibody
      • C1QG antibody
      • Complement C1q subcomponent subunit C antibody
      • Complement component 1, q subcomponent, C chain antibody
      • complement component 1, q subcomponent, gamma polypeptide antibody
      see all

    Anti-C1QC antibody 图像

    • All lanes : Anti-C1QC antibody (ab92689) at 1/500 dilution

      Lane 1 : Rat lung cell lysate in absence of blocking peptide
      Lane 2 : Rat lung cell lysate in presence of blocking peptide (10 µg)

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 26 kDa
    • ab92689 at 1/50 dilution staining C1QC in Human lung carcinoma in (1) absence of blocking peptide and (2) presence of blocking peptide by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

    Anti-C1QC antibody (ab92689)参考文献

    ab92689 has not yet been referenced specifically in any publications.

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