RabMAb

Anti-C1QA抗体[EPR2979(2)] (ab108325)

概述

  • 产品名称Anti-C1QA抗体[EPR2979(2)]
    参阅全部 C1QA 一抗
  • 描述
    兔单克隆抗体[EPR2979(2)] to C1QA
  • 经测试应用适用于: WB, IP, ICCmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human C1QA.

  • 阳性对照
    • Humanplasma and serum lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

  • 形式Liquid
  • 存放说明Frozen Stock (-20C). Shelf life 12 months.
  • 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EPR2979(2)
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab108325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 26 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt or IHC-P.
  • 靶标

    • 功能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
    • 疾病相关Defects in C1QA are the cause of complement component C1qA deficiency (C1QAD) [MIM:120550]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
    • 序列相似性Contains 1 C1q domain.
      Contains 1 collagen-like domain.
    • 翻译后修饰O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C1qa antibody
      • C1QA_HUMAN antibody
      • Complement C1q subcomponent subunit A antibody
      • Complement component 1 q subcomponent A chain antibody
      • Complement component 1 q subcomponent alpha polypeptide antibody
      • Complement component C1q A chain antibody
      see all

    Anti-C1QA antibody [EPR2979(2)] 图像

    • All lanes : Anti-C1QA antibody [EPR2979(2)] (ab108325) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human serum lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 26 kDa

    Anti-C1QA antibody [EPR2979(2)] (ab108325)参考文献

    ab108325 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"