Anti-C1QA抗体- C-terminal (ab85208)

概述

  • 产品名称Anti-C1QA抗体- C-terminal
    参阅全部 C1QA 一抗
  • 描述
    兔多克隆抗体to C1QA - C-terminal
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH-conjugated synthetic peptide designed within the C-terminal region of Human C1QA

  • 阳性对照
    • Jurkat cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Ammonium Sulphate Precipitation
  • 纯化说明Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab85208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 26 kDa.
ELISA 1/1000.

靶标

  • 功能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 疾病相关Defects in C1QA are the cause of complement component C1qA deficiency (C1QAD) [MIM:120550]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • 序列相似性Contains 1 C1q domain.
    Contains 1 collagen-like domain.
  • 翻译后修饰O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C1qa antibody
    • C1QA_HUMAN antibody
    • Complement C1q subcomponent subunit A antibody
    • Complement component 1 q subcomponent A chain antibody
    • Complement component 1 q subcomponent alpha polypeptide antibody
    • Complement component C1q A chain antibody
    see all

Anti-C1QA antibody - C-terminal 图像

  • Anti-C1QA antibody - C-terminal (ab85208) at 1/50 dilution + Jurkat cell line lysates at 35 µg

    Predicted band size : 26 kDa
    Observed band size : 26 kDa
    Additional bands at : 52 kDa (possible dimer).

Anti-C1QA antibody - C-terminal (ab85208)参考文献

ab85208 has not yet been referenced specifically in any publications.

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