Anti-C1q抗体(Biotin) (ab48341)

概述

  • 产品名称Anti-C1q抗体(Biotin)
    参阅全部 C1q 一抗
  • 描述
    兔多克隆抗体to C1q (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: WB, RIAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human C1q purified from Human plasma.

性能

应用

Our Abpromise guarantee covers the use of ab48341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 26 kDa.
RIA Use a concentration of 5 µg/ml.

靶标

  • 功能C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 疾病相关Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
  • 序列相似性Contains 1 C1q domain.
    Contains 1 collagen-like domain.
  • 翻译后修饰O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C1qa antibody
    • C1QA_HUMAN antibody
    • C1QB antibody
    • C1QC antibody
    • Complement C1q subcomponent subunit A antibody
    • Complement C1q subcomponent subunit B antibody
    • Complement C1q subcomponent subunit C antibody
    • Complement component 1 q subcomponent alpha polypeptide antibody
    • Complement component C1q A chain antibody
    • Complement component C1q B chain antibody
    • Complement component C1q C chain antibody
    see all

Anti-C1q antibody (Biotin) (ab48341)参考文献

ab48341 has not yet been referenced specifically in any publications.

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