Anti-COSMC抗体(ab68310)
Key features and details
- Mouse polyclonal to COSMC
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-COSMC抗体
参阅全部 COSMC 一抗 -
描述
小鼠多克隆抗体to COSMC -
宿主
Mouse -
特异性
This antibody is reactive against mammalian transfected lysate. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human COSMC. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_001011551.1 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
-
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab68310于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Detects a band of approximately 32 kDa (predicted molecular weight: 36 kDa).
|
说明 |
---|
WB
1/500 - 1/1000. Detects a band of approximately 32 kDa (predicted molecular weight: 36 kDa). |
靶标
-
功能
Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). -
组织特异性
Ubiquitously expressed. Abundantly expressed in salivary gland, stomach, small intestine, kidney, and testis and at intermediate levels in whole brain, cerebellum, spinal cord, thymus, spleen, trachea, lung, pancreas, ovary, and uterus. -
疾病相关
Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN) [MIM:300622]. Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. -
序列相似性
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. -
细胞定位
Membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 29071 Human
- Omim: 300611 Human
- SwissProt: Q96EU7 Human
- Unigene: 643920 Human
-
别名
- HSPC067 antibody
- 3-galactosyltransferase 2 antibody
- Beta 1,3 galactosyltransferase 2 antibody
see all
图片
-
Anti-COSMC antibody (ab68310) at 1/500 dilution + human liver tissue lysate at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 36 kDa
Observed band size: 32 kDa why is the actual band size different from the predicted? -
All lanes : Anti-COSMC antibody (ab68310) at 1/500 dilution
Lane 1 : COSMC transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 36 kDa
Observed band size: 32 kDa why is the actual band size different from the predicted?
实验方案
数据表及文件
-
Datasheet download
文献 (0)
ab68310 尚未被引用在任何文献中。