Anti-C16orf57抗体(ab67059)

概述

  • 产品名称
    Anti-C16orf57抗体
    参阅全部 C16orf57 一抗
  • 描述
    小鼠多克隆抗体to C16orf57
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-266 of Human C16orf57

  • 阳性对照
    • transfected 293T cells lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 30 kDa).

靶标

  • 疾病相关
    Defects in C16orf57 are the cause of poikiloderma with neutropenia (PN) [MIM:604173]. PN is a genodermatosis characterized by poikiloderma, pachyonychia and chronic neutropenia. The disorder starts as a papular erythematous rash on the limbs during the first year of life. It gradually spreads centripetally and, as the papular rash resolves, hypo- and hyperpigmentation result, with development of telangiectasias. Another skin manifestation is pachyonychia, but alopecia and leukoplakia are distinctively absent. One of the most important extracutaneous symptoms is an increased susceptibility to infections, mainly affecting the respiratory system, primarily due to a chronic neutropenia and to neutrophil functional defects. Bone marrow abnormalities account for neutropenia and may evolve into myelodysplasia associated with the risk of leukemic transformation. Poikiloderma with neutropenia shows phenotypic overlap with Rothmund-Thomson syndrome.
  • 序列相似性
    Belongs to the UPF0406 family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C16orf57 antibody
    • Chromosome 16 open reading frame 57 antibody
    • CP057_HUMAN antibody
    • FLJ13154 antibody
    • UPF0406 protein C16orf57 antibody
    see all

Anti-C16orf57 antibody 图像

  • All lanes : Anti-C16orf57 antibody (ab67059) at 1/500 dilution

    Lane 1 : C16orf57 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

    Predicted band size : 30 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)

实验方案

Anti-C16orf57 antibody (ab67059)参考文献

ab67059 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Application
Western blot
Sample
Human Cell lysate - whole cell (WI-38)
Loading amount
50 µg
Specification
WI-38
Gel Running Conditions
Reduced Denaturing (12% gel)
Blocking step
Milk as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
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提交于 Sep 16 2010

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