Anti-C1 Inactivator抗体[KT28] (ab53365)

概述

  • 产品名称Anti-C1 Inactivator抗体[KT28]
    参阅全部 C1 Inactivator 一抗
  • 描述
    小鼠单克隆抗体[KT28] to C1 Inactivator
  • 经测试应用适用于: Indirect ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified C1 inactivator from human blood

性能

应用

Our Abpromise guarantee covers the use of ab53365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Indirect ELISA
  • 应用说明I-ELISA: Use at a concentration of 5 µg/ml as primary antibody.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
    • 疾病相关Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
    • 序列相似性Belongs to the serpin family.
    • 翻译后修饰Highly glycosylated (49%) with N- and O-glycosylation.
      Can be proteolytically cleaved by E.coli stcE.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C1 esterase inhibitor antibody
      • C1 Inh antibody
      • C1 inhibiting factor antibody
      • C1 inhibitor antibody
      • C1-inhibiting factor antibody
      • C1IN antibody
      • C1Inh antibody
      • C1NH antibody
      • complement component 1 inhibitor antibody
      • esterase inhibitor antibody
      • HAE1 antibody
      • HAE2 antibody
      • IC1_HUMAN antibody
      • Plasma protease C1 inhibitor antibody
      • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
      • serine/cysteine proteinase inhibitor clade G member 1 antibody
      • Serpin G1 antibody
      • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
      • SERPING1 antibody
      see all

    Anti-C1 Inactivator antibody [KT28] (ab53365)参考文献

    ab53365 has not yet been referenced specifically in any publications.

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