概述

  • 产品名称Anti-C1 Inactivator抗体
    参阅全部 C1 Inactivator 一抗
  • 描述
    兔多克隆抗体to C1 Inactivator
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 77-390 of Human C1 Inactivator (NP_000053).

  • 阳性对照
    • 293T, A431, H1299, HeLa S3, HepG2, MOLT4 and Raji cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab97348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.

靶标

  • 功能Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • 疾病相关Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • 序列相似性Belongs to the serpin family.
  • 翻译后修饰Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C1 esterase inhibitor antibody
    • C1 Inh antibody
    • C1 inhibiting factor antibody
    • C1 inhibitor antibody
    • C1-inhibiting factor antibody
    • C1IN antibody
    • C1Inh antibody
    • C1NH antibody
    • complement component 1 inhibitor antibody
    • esterase inhibitor antibody
    • HAE1 antibody
    • HAE2 antibody
    • IC1_HUMAN antibody
    • Plasma protease C1 inhibitor antibody
    • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
    • serine/cysteine proteinase inhibitor clade G member 1 antibody
    • Serpin G1 antibody
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
    • SERPING1 antibody
    see all

Anti-C1 Inactivator antibody 图像

  • All lanes : Anti-C1 Inactivator antibody (ab97348) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : HeLa S3 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 55 kDa

Anti-C1 Inactivator antibody (ab97348)参考文献

This product has been referenced in:
  • Hansen HG  et al. Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Sci Rep 5:18016 (2015). WB . Read more (PubMed: 26657798) »

See 1 Publication for this product

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