Anti-SERPING1抗体(ab229209)
Key features and details
- Rabbit polyclonal to SERPING1
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-SERPING1抗体
参阅全部 SERPING1 一抗 -
描述
兔多克隆抗体to SERPING1 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Recombinant fragment within Human SERPING1 (internal sequence). The exact sequence is proprietary.
Database link: P05155 -
阳性对照
- WB: Human, mouse and rat plasma. IHC-P: Human hepatoma tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab229209于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/1000.
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WB |
1/500 - 1/10000. Predicted molecular weight: 55 kDa.
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说明 |
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IHC-P
1/100 - 1/1000. |
WB
1/500 - 1/10000. Predicted molecular weight: 55 kDa. |
靶标
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功能
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. -
疾病相关
Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional. -
序列相似性
Belongs to the serpin family. -
翻译后修饰
Highly glycosylated (49%) with N- and O-glycosylation.
Can be proteolytically cleaved by E.coli stcE. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 710 Human
- Entrez Gene: 12258 Mouse
- Entrez Gene: 295703 Rat
- Omim: 606860 Human
- SwissProt: P05155 Human
- SwissProt: P97290 Mouse
- SwissProt: Q6P734 Rat
- Unigene: 384598 Human
see all -
别名
- C1 esterase inhibitor antibody
- C1 Inh antibody
- C1 inhibiting factor antibody
see all
图片
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Anti-SERPING1 antibody (ab229209) at 1/5000 dilution + Human plasma at 30 µg
Predicted band size: 55 kDa7.5% SDS-PAGE gel.
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Paraffin-embedded human hepatoma tissue stained for SERPING1 using ab229209 at 1/500 dilution in immunohistochemical analysis.
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Anti-SERPING1 antibody (ab229209) at 1/1000 dilution + Mouse plasma at 50 µg
Predicted band size: 55 kDa10% SDS-PAGE gel.
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Anti-SERPING1 antibody (ab229209) at 1/1000 dilution + Rat plasma at 50 µg
Predicted band size: 55 kDa10% SDS-PAGE gel.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab229209 被引用在 2 文献中.
- Sastre-Oliva T et al. The Influence of Coronary Artery Disease in the Development of Aortic Stenosis and the Importance of the Albumin Redox State. Antioxidants (Basel) 11:N/A (2022). PubMed: 35204200
- Ni Y et al. Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation. Int J Biol Sci 18:5168-5184 (2022). PubMed: 35982894