Anti-c-Myc抗体[SPM237], prediluted (ab17767)


  • 产品名称Anti-c-Myc抗体[SPM237], prediluted
    参阅全部 c-Myc 一抗
  • 描述
    小鼠单克隆抗体[SPM237] to c-Myc, prediluted
  • 特异性The protein detected by ab17767 is 64-67kDa
  • 经测试应用适用于: IHC-P, IHC-FoFrmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat, Chicken
  • 免疫原

    Synthetic peptide, corresponding to C terminal amino acids 408-439 of Human c-Myc.

  • 表位aa410-419
  • 阳性对照
    • Raji cells, Breast carcinoma



Our Abpromise guarantee covers the use of ab17767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明Immunohistology (Formalin/paraffin). Working dilution: ab17767 is ready-to-use for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. The optimal dilution for a specific application should be determined by the investigator.
  • 靶标

    • 功能Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    • 疾病相关Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
      Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
    • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
    • 翻译后修饰Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
      Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex.
    • 细胞定位Nucleus > nucleoplasm. Nucleus > nucleolus.
    • Information by UniProt
    • 数据库链接
    • 形式c-Myc is also expressed in the cytoplasm.
    • 别名
      • AU016757 antibody
      • Avian myelocytomatosis viral oncogene homolog antibody
      • bHLHe39 antibody
      • c Myc antibody
      • Class E basic helix-loop-helix protein 39 antibody
      • MRTL antibody
      • Myc antibody
      • Myc protein antibody
      • Myc proto oncogene protein antibody
      • Myc proto-oncogene protein antibody
      • myc-related translation/localization regulatory factor antibody
      • MYC_HUMAN antibody
      • Myc2 antibody
      • MYCC antibody
      • Myelocytomatosis oncogene antibody
      • Niard antibody
      • Nird antibody
      • Oncogene Myc antibody
      • OTTHUMP00000158589 antibody
      • Proto-oncogene c-Myc antibody
      • Protooncogene homologous to myelocytomatosis virus antibody
      • RNCMYC antibody
      • Transcription factor p64 antibody
      • Transcriptional regulator Myc-A antibody
      • V-Myc avian myelocytomatosis viral oncogene homolog antibody
      • v-myc myelocytomatosis viral oncogene homolog (avian) antibody
      see all

    Anti-c-Myc antibody [SPM237], prediluted 图像

    • Formalin fixed human breast carcinoma stained with anti-c-myc (ab17767)

    Anti-c-Myc antibody [SPM237], prediluted (ab17767)参考文献

    ab17767 has not yet been referenced specifically in any publications.

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