概述

  • 产品名称Anti-c-Myb抗体[EPR718(2)]
    参阅全部 c-Myb 一抗
  • 描述
    兔单克隆抗体[EPR718(2)] to c-Myb
  • 经测试应用适用于: IHC-P, WBmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human c-Myb.

  • 阳性对照
    • Jurkat and MOLT4 cell lysates; Human colon tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EPR718(2)
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab109127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. PubMed: 22569827
WB 1/1000 - 1/10000. Predicted molecular weight: 72 kDa.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
    • 序列相似性Contains 3 HTH myb-type DNA-binding domains.
    • 结构域Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
    • 翻译后修饰Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
      Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C myb antibody
      • c myb protein (140 AA) antibody
      • c-myb protein (140 AA) antibody
      • c-myb_CDS antibody
      • c-myb10A_CDS antibody
      • c-myb13A_CDS antibody
      • c-myb14A_CDS antibody
      • c-myb8B_CDS antibody
      • Cmyb antibody
      • efg antibody
      • Myb antibody
      • MYB_HUMAN antibody
      • ONCOGENE AMV antibody
      • Oncogene MYB antibody
      • Proto oncogene c Myb antibody
      • Proto-oncogene c-Myb antibody
      • Transcriptional activator Myb antibody
      • v myb avian myeloblastosis viral oncogene homolog antibody
      • v-myb avian myeloblastosis viral oncogene homolog antibody
      see all

    Anti-c-Myb antibody [EPR718(2)] 图像

    • All lanes : Anti-c-Myb antibody [EPR718(2)] (ab109127) at 1/1000 dilution

      Lane 1 : Jurkat cell lysates
      Lane 2 : MOLT4 cell lysates

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 72 kDa

    Anti-c-Myb antibody [EPR718(2)] (ab109127)参考文献

    This product has been referenced in:
    • Cyr AR  et al. TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene N/A:N/A (2014). Read more (PubMed: 24469049) »
    • Baron BW  et al. GFI1B, EVI5, MYB-Additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. Blood Cells Mol Dis N/A:N/A (2013). IHC . Read more (PubMed: 23910958) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"