Bupropion hydrochloride (ab120534)

概述

  • 产品名称
    Bupropion hydrochloride
  • 描述
    Non-selective DAT/NET抑制剂
  • 生物学描述
    Non-selective dopamine and norepinephrine transporter (DAT/NET) inhibitor (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters, respectively). Nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 1.8 μM at α2β2 receptor). Displays antidepressant activity.
  • 纯度
    > 98%

性能

文献

This product has been referenced in:
  • Budzynska B & Biala G Effects of bupropion on the reinstatement of nicotine-induced conditioned place preference by drug priming in rats. Pharmacol Rep 63:362-71 (2011). Read more (PubMed: 21602591) »
  • Damaj MI  et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol 66:675-82 (2004). Read more (PubMed: 15322260) »
  • Dwoskin LP  et al. Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent. CNS Drug Rev 12:178-207 (0). Read more (PubMed: 17227286) »

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